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  • Title: Stereocontrolled total synthesis of pancratistatin.
    Author: Kim S, Ko H, Kim E, Kim D.
    Journal: Org Lett; 2002 Apr 18; 4(8):1343-5. PubMed ID: 11950358.
    Abstract:
    A new total synthesis of the antitumor alkaloids, pancratistatin (1), has been accomplished from readily available staring materials. The Claisen rearrangement of dihydropyranethylene 5 was employed to construct the A and C rings. Stereo- and regiocontrolled functional group interchange, such as iodolactonization, dihydroxylations, and a cyclic sulfate elimination reaction, allows for the production of the target natural product. [reaction: see text]
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