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  • Title: [The changes in the heart and erythrocyte L-arginine transport of spontaneously hypertensive rats].
    Author: Zheng HZ, Wang XH, Liu XY, Tang CS, Liu NK.
    Journal: Sheng Li Xue Bao; 2000 Aug; 52(4):323-8. PubMed ID: 11951116.
    Abstract:
    Changes of L-arginine/nitric oxide pathway in heart and of L arginine transport in erythrocytes and their relationship were investigated in spontaneously hypertensive rats (SHR). 12 and 16 weeks old SHR, 16 weeks old SHR with captopril treatment for 4 weeks and 16 weeks old Wistar-Kyoto (WKY) rats were used. L arginine transport of myocardial ventricular tissue and erythrocytes, total nitric oxide synthase (tNOS) activity, nitrite and nitrate (NO(2) + NO(3)) and cyclic GMP (cGMP) content in myocardium were measured. The result showed that in myocardial ventricular tissue of SHR L-arginine transport decreased significantly with V(max) of the high-affinity transport being decreased by 24.3% (P<0.05, 12W group), 36.4% (P<0.01, 16W group) as compared with WKY group. Michaelis constant (K(m)) of low affinity transport was significantly lower than that of WKY group. NO(2) + NO(3) and cGMP content were respectively decreased by 24.6%, 19.8% (P>0.05, P<0.05, 12W group), 52.5%, 60.4% (P<0.05, P<0.01, 16W group) and 14.8%, 23% (P>0.05, P<0.05, SHR+C group) as compared with WKY group. But the K(m) of L-arginine high-affinity transport and the V(max) of low affinity transport and tNOS activity were not significantly changed. In erythrocytes, the changes of L-arginine transport coincided with those of myocardial tissue. The V(max) had significant positive correlation with the V(max) of high-affinity transport in myocardial tissue, r=0.5606, P=0.01 and had negative correlation with left ventricular weight to body weight radio, r=0.6231,P<0.01. These results indicate that the activity of L-arginine/nitric oxide pathway inhibited in myocardial tissue of SHR. The correlation between the inhibitory degree of L-arginine/nitric oxide pathway and the degree of ventricular hypertrophy is negative. The changes of L-arginine transport in erythrocytes coincide with those in myocardium.
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