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  • Title: Diffusion MR imaging in glioma: does it have any role in the pre-operation determination of grading of glioma?
    Author: Lam WW, Poon WS, Metreweli C.
    Journal: Clin Radiol; 2002 Mar; 57(3):219-25. PubMed ID: 11952318.
    Abstract:
    AIM: To investigate the role of the diffusion MR weighted sequence in the pre-operative grading of gliomas, and its application in defining the different components of these tumours. MATERIALS AND METHODS: Seventeen patients with gliomas (eight high grade, nine low grade) had diffusion weighted imaging. Apparent diffusion coefficients (ADCs) of different components of tumours were measured. RESULTS: ADC of the cystic portion of the tumour was significantly higher than ADCs of the enhanced tumour, non-enhanced tumour and perifocal oedema (P < 0.01). No significant difference in ADC values between low grade and high grade glioma (P > 0.7) was found nor was there any difference between oligoglioma and non-oligoglioma (P > 0.29). CONCLUSION: ADC value was useful to differentiate the cystic from the solid components of the tumours. However, it was not useful in pre-operative grading of glioma.
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