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  • Title: [Eotaxin in induced sputum in patients with asthma and chronic bronchitis: relationship with airway inflammation].
    Author: Fu J, Chen P, Xiang X.
    Journal: Zhonghua Jie He He Hu Xi Za Zhi; 2002 Jan; 25(1):29-32. PubMed ID: 11953096.
    Abstract:
    OBJECTIVE: Investigate the roles of eotaxin (chemotactic factor of eosinophils) in pathogenesis of eosinophilic airway inflammation and airflow obstruction. METHODS: 33 patients in exacerbations with chronic bronchitis (CB group), chronic asthmatic bronchitis (CAB group) and bronchial asthma (BA group) (11 cases respectively) and 7 healthy volunteers as controls (C group) have participated in lung function test and sputum induction. The concentration of eotaxin in supernatant was measured by sandwich enzyme linked immunosorbent assay (ELISA). RESULTS: The differences of the eosinophil (EOS)/leukocyte (Leu)% in CAB group [(23.4 +/- 5.8)%], BA group [(20.7 +/- 3.1)%] and in CB group [(11.6 +/- 2.6)%], C group [(1.2 +/- 0.3)%] are significant (P < 0.001), and the differences of the level of eotaxin in CAB group [(0.290 +/- 0.170) g/L], BA group [(0.240 +/- 0.140) g/L] and in CB group [(0.120 +/- 0.020) g/L], C group [(0.030 +/- 0.050) g/L] are also significant [CAB group-CB group (P = 0.007); CAB group-C group (P < 0.001); BA group-CB group (P = 0.018); BA group-C group (P = 0.001)], but the differences of those in BA group and in CAB group are not significant (P = 0.196, 0.490). The EOS/Leu % is significantly inversely correlated with the percentage of the first second forced expiratory volume/predicted value (FEV(1)%) in CAB group (r = -0.921, P < 0.001). The EOS/Leu % and the level of eotaxin are significantly inversely correlated with FEV(1)% respectively in BA group (r = -0.663, -0.643, P = 0.026, 0.033). The level of eotaxin in induced sputum is significantly positively correlated with the EOS/Leu % in CAB group (r = 0.658, P = 0.028) and BA group (r = 0.634, P = 0.036), but it is not correlated with any of Neu/Leu %, macrophage (Macro)/Leu % or lymphocyte (Lym)/Leu % in any group (P > 0.05). CONCLUSION: Eotaxin possibly particulates in eosinophilic airway inflammation in patients with BA and CAB by selective chemotactic activity on eosinophil.
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