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  • Title: [Changes of antioxidative capacity and endothelial function before and after treatment among patients with high altitude pulmonary edema].
    Author: Fu Z, Jiang P, Ren Y, Peng S, Li H, Luo X, Zou Z, Zhao M.
    Journal: Zhonghua Jie He He Hu Xi Za Zhi; 2002 Jan; 25(1):33-5. PubMed ID: 11953097.
    Abstract:
    OBJECTIVE: To investigate the changes of antioxidative capacity and endothelial function among patients with high altitude pulmonary edema (HAPE). METHODS: The serum levels of SOD, MDA, GSH, NO, NOS and ET-1 were measured before and after treatment among 34 cases of patients with HAPE, and 20 local healthy volunteers served as control. RESULTS: The serum levels of SOD, GSH, NO and NOS were lower in patient-group before treatment than after treatment and those in control-group significantly (P < 0.01), while the concentration of MDA and ET-1 were higher in patient-group before treatment than after treatment and those in the control-group significantly (P < 0.01). The serum levels of SOD, MDA, GSH, NO, NOS and ET-1 were not different between patient-group after treatment and the control-group (P > 0.05). CONCLUSION: The results indicated that changes of SOD, MDA, GSH, NO, NOS and ET-1 may participate in the course of HAPE.
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