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  • Title: [The role of taurine as hydroxyl radical inhibitor and its effect on lipid peroxidation in selenite cataract].
    Author: Zhang W, Chen C, Dong B, Lu D, Chen D.
    Journal: Zhonghua Yan Ke Za Zhi; 2002 Mar; 38(3):157-60. PubMed ID: 11955321.
    Abstract:
    OBJECTIVE: To study the role of taurine as hydroxyl radical and superoxide anion radical inhibitor in vitro and evaluate the effect of intraperitoneal injection of taurine on peroxidation in rat selenite cateractous lenses. METHODS: Electron spin resonance (ESR) was used to detect hydroxyl radical and superoxide anion radical. The concentrations of malondialdehyde (MDA) in normal lenses, selenite-injected lenses and taurine-treated lenses were measured on the 2 nd, 5 th, 9 th and 14 th days after the first injection of selenite. RESULTS: Taurine was an inhibitor of hydroxyl radical and superoxide anion radical. Its effect was very obvious. The concentration of MDA in selenite-injected lenses increased significantly after injection of selenite and became higher with the development of cataract. The concentration of MDA in taurine-treated lenses was lower than that in selenite-injected lenses. CONCLUSION: Taurine is an inhibitor of hydroxyl radical and superoxide radical. It can prevent lipid peroxidation in selenite cataractous lenses.
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