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  • Title: Interleukin-6 and the development of social disruption-induced glucocorticoid resistance.
    Author: Stark JL, Avitsur R, Hunzeker J, Padgett DA, Sheridan JF.
    Journal: J Neuroimmunol; 2002 Mar; 124(1-2):9-15. PubMed ID: 11958817.
    Abstract:
    Following social disruption (SDR) stress in male mice, corticosterone resistance of splenocytes was accompanied by enhanced LPS-stimulated interleukin (IL)-6 secretion. The present study examined the role of IL-6 in the development of corticosterone resistance. Addition of IL-6 to control splenocyte cultures did not induce corticosterone resistance. SDR also elevated IL-6 in plasma and liver, but not in spleen. IL-6 deficient mice that were exposed to SDR developed glucocorticoid resistance despite the absence of systemic IL-6. These findings suggest that although SDR enhanced IL-6 responses, IL-6 was not essential for the development of stress-induced splenocyte corticosterone resistance.
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