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  • Title: Antibacterial activity of G6-quaternary ammonium derivatives of a lipophilic vancomycin analogue.
    Author: Blizzard TA, Kim RM, Morgan JD, Chang J, Kohler J, Kilburn R, Chapman K, Hammond ML.
    Journal: Bioorg Med Chem Lett; 2002 Mar 25; 12(6):849-52. PubMed ID: 11958977.
    Abstract:
    A series of G6-amino derivatives of a lipophilic vancomycin analogue was prepared. Antibacterial activity of the analogues was inversely proportional to the degree of substitution of the G6-nitrogen. The fully substituted (quaternary) analogues were essentially inactive against vanA phenotype VREF strains but retained substantial activity against other bacteria, a profile reminiscent of teicoplanin.
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