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  • Title: Effect of temperature on stability of marker constituents in Echinacea purpurea root formulations.
    Author: Livesey J, Awang DV, Arnason JT, Letchamo W, Barrett M, Pennyroyal G.
    Journal: Phytomedicine; 1999 Nov; 6(5):347-9. PubMed ID: 11962542.
    Abstract:
    Stability of an alkamide and a phenolic phytochemical marker in a hydro-alcoholic extract of Echinacea purpurea root and a dried powder prepared by evaporation of the extract was assessed in storage for 7 months at three temperature regimes: -20, 25 and 40 degrees Celsius. In the extract, the major alkamide, dodeca-2E, 4E, 8Z, 10E/Z-tetraenoic acid isobutyl amide, was not significantly affected by storage at any of the temperatures, but cichoric acid content declined as significantly (P = 0.05) at both 25 degrees C and 40 degrees C as compared to low-temperature storage. In the powder, the major alkamide showed a significantly reduced level at 25 degrees C and 40 degrees C while cichoric acid did not decline significantly. These results suggest that more attention should be given to the effect of formulation and temperature on storage of Echinacea products.
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