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  • Title: Recent developments in diisocyanate asthma.
    Author: Wisnewski AV, Redlich CA.
    Journal: Curr Opin Allergy Clin Immunol; 2001 Apr; 1(2):169-75. PubMed ID: 11964686.
    Abstract:
    Despite recent advances in our understanding of diisocyanate-induced asthma, this disease remains a perplexing phenomenon. Studies reported in the past year have focused on: (i) diisocyanate antigens; (ii) the role of airway and skin epithelium; (iii) human immune responses to exposure; (iv) neurogenic pathways; and (v) genetic factors that may confer susceptibility. These studies support the hypothesis that diisocyanate asthma results from the host immune response to these chemicals, and may represent a mixed T helper type 1/2 response. A better understanding of the pathogenesis of diisocyanate asthma should facilitate the development of better diagnostic tests and strategies for disease surveillance and intervention.
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