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  • Title: Some biochemical effects of chloral hydrate in an infant with a tyrosinemia-like syndrome.
    Author: Watts RW, Chalmers RA, Liberman MM, Lawson AM.
    Journal: Pediatr Res; 1975 Dec; 9(12):875-8. PubMed ID: 1196703.
    Abstract:
    An infant with a combination of clinical and biochemical features resembling those found in hereditary tyrosinemia ("inborn hepatorenal dysfunction with tyrosyluria") but with spontaneous recovery is described briefly. The child also had severe congenital hydrocephalus, and was being given chloral hydrate. She was not treated by restriction of dietary phenylalanine and tyrosine. The abnormal aromatic aciduria was unaltered by ascorbic acid administration. The results of loading tests with phenylalanine, tyrosine, and sodium 4-hydroxyphenylpyruvate are compatible with the existence of a partial block in the oxidation of 4-hydroxyphenylpyruvate to homogentisate which was exacerbated by administering chloral hydrate.
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