These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Anti-thyroid drug methimazole: X-ray characterization of two novel ionic disulfides obtained from its chemical oxidation by I(2).
    Author: Aragoni MC, Arca M, Demartin F, Devillanova FA, Garau A, Isaia F, Lippolis V, Verani G.
    Journal: J Am Chem Soc; 2002 May 01; 124(17):4538-9. PubMed ID: 11971682.
    Abstract:
    Interaction of methimazole (MMI, 1-methyl-imidazole-2-thione) with I2 in solvents having different polarity gives two new stable compounds containing a dication disulfide and a monocation disulfide arranged in dimers, respectively. These two species could represent effective intermediates in the reaction of MMI with an active iodine species in the thyroid gland and therefore shed more light on the mechanism of action of MMI as an antithyroid drug.
    [Abstract] [Full Text] [Related] [New Search]