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  • Title: Dynamic pattern of IGF-I and chosen biochemical markers of bone metabolism in a rat model of postmenopausal osteoporosis.
    Author: Ostrowska Z, Kos-Kudla B, Marek B, Kajdaniuk D, Ciesielska-Kopacz N.
    Journal: Endocr Regul; 2002 Mar; 36(1):9-17. PubMed ID: 11971746.
    Abstract:
    OBJECTIVE: To assess the relationship between the dynamic pattern of IGF-I levels and chosen biochemical markers of bone metabolism in ovariectomized rats - a model of postmenopausal osteoporosis. METHODS: Six-month-old rats were randomized to sham operation (control group) or ovariectomy. Serum levels of insulin-like growth factor (IGF-I) and chosen biochemical markers of bone metabolism (alkaline phosphatase - ALP, carboxyterminal propeptide of type I procollagen - PICP, cross-linked carboxyterminal telopeptide of type I collagen - ICTP in serum as well as urinary excretion of hydroxyproline - HYP and total calcium - Ca) were measured before (group 0) and 1, 2, 3, 4, 6, 8, 12, 16, 20, 24 and 28 weeks after the operation. RESULTS: In a model of experimental osteoporosis induced by ovariectomy in female rats a distinct tendency to decrease the IGF-I concentrations was shown. Differences were significant in relation to the control group in a period from 2 to 28 weeks after operation. Ovariectomy stimulated the values of studied markers of bone metabolism; it was more intensified in regard to resorption markers. Significant ICTP and HYP concentrations' changes, in relation to the control group, were shown in the some period and total calcium - from 2 to 16 weeks after ovariectomy. However, the values of studied markers of bone formation were generally changing to a slight degree. Significant differences of ALP activity, in relation to the control group, were observed only at 8 and 20 weeks, while those of PICP concentrations were found at in 4, 8 and 12 weeks after the operation. The alterations in the levels of IGF-I correlated significantly and negatively with the changes in ALP activity as well as in PICP, ICTP, HYP and Ca concentrations both in ovariectomized and control rats. This relation was more expressed in the ovariectomized group. CONCLUSIONS: Our findings suggest that secondary changes in IGF-I concentration, due to the deficiency of sex hormones, results in altered bone metabolism in ovariectomized rats.
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