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  • Title: Delayed excretion of conjugated sulphamethoxazole in uraemia.
    Author: Gotloib L, Mines M, Servadio C, Kohan R.
    Journal: Proc Eur Dial Transplant Assoc; 1975; 11():405-10. PubMed ID: 1197265.
    Abstract:
    Persistence in the serum of free and conjugated sulphamethoxazole was estimated in five normal controls and in nine uraemic patients with creatinine clearances under 20 ml/min, after a single one-gram dose of the drug. In the uraemic group delayed disappearance of the free drug was found. Conjugated sulphamethoxazole retention was 62.44% at 24 hr after the oral load, and 13.7% 19 days later. Risk of accumulation of sulphamethoxazole in uraemia is emphasised. Re-evaluation of the use of this drug in patients with impaired renal function is recommended.
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