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  • Title: Heparin-induced life-threatening hyperkalemia.
    Author: Gheno G, Savarino C, Vellar S, Cinetto L.
    Journal: Ann Ital Med Int; 2002; 17(1):51-3. PubMed ID: 11975115.
    Abstract:
    Hyperkalemia may occur in many clinical settings and lead to serious events. Heparin-induced hyperkalemia is presumably less well recognized than other untoward effects of heparin treatment and more frequent than commonly perceived. To draw attention to this clinically relevant occurrence, we report 2 cases of life-threatening bradyarrhythmia associated with heparin prescription. Heparin-induced hyperkalemia is mediated by an enzymatic block in the synthesis of aldosterone; however, in most cases severe hyperkalemia occurs in the presence of additional factors influencing potassium homeostasis. Patients treated with heparin should be stratified and adequately monitored according to the outlined risk profile.
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