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  • Title: Morphine enhancement of shuttle avoidance prevented by alpha-methyltyrosine.
    Author: Davis WM, Smith TP.
    Journal: Psychopharmacologia; 1975 Oct 14; 44(1):95-7. PubMed ID: 1197583.
    Abstract:
    Rats were given 6 days of training (180 trials) to make a two-way (shuttle) avoidance response. "Poor performers" making less than 50% avoidances in the 6th block of 30 tials were given drug treatments on the next 2 days. Both morphine sulfate (15 mg/kg) and d-amphetamine sulfate (1 mg/kg) increased the avoidance level by 70-100%. Prior treatment with alpha-methyltyrosine (50 mg/kg) prevented the effects of both drugs. Nalorphine hydrochloride (5 mg/kg) also blocked the effect of morphine. The action of alpha-methyltyrosine to block enhancement of avoidance is taken to indicate that this effect of morphine is attributable to a catecholamine-dependent excitatory component of its activity profile.
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