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  • Title: Nucleolar organizer regions in laryngeal cancer.
    Author: Klatka J, Skomra D.
    Journal: Ann Univ Mariae Curie Sklodowska Med; 2001; 56():417-21. PubMed ID: 11977351.
    Abstract:
    The purpose of this study was to estimate the prognostic value of the AgNORs count per nucleus in laryngeal cancer. The sections of diagnostic, formalin-fixed and paraffin-embedded specimens from 48 patients with T1-4 tumours were stained with silver nitrate for visualization of NORs (AgNORs). The correlation between AgNORs score and tumour clinicopathological features was estimated. The mean AgNOR number per nucleus was 2.73 +/- 0.87 (range 1.48-4.38). The AgNOR counts did not correlate with the stage of the disease, patient survival rate and N stage. A significant correlation between the mean AgNORs number and various stages of histological differentiation of carcinoma was observed (p < 0.05).
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