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  • Title: On the pathogenicity of nonstable Brucella L-forms and their revertants.
    Author: Grekova NA, Tolmacheva TA, Vershilova PA.
    Journal: J Hyg Epidemiol Microbiol Immunol; 1979; 23(2):129-34. PubMed ID: 119809.
    Abstract:
    The pathogenicity of B. abortus 870 L-forms obtained by long-term passaging of virulent culture on media with penicillin and of revertants obtained in vitro and in vivo was studied. L-form cultures stimulated only a mild response of the reticulo-endothelial system of the animal organism, at the same time displaying a certain level of toxicity. In vitro revertants approximated to L-forms, while in vivo revertants stood closer to the initial virulent culture, as regards pathogenicity. This seems to be evidence of a potential danger of brucella L-forms for the human and animal organisms.
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