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  • Title: Periodic binding of troponin C.I and troponin I to tropomyosin-actin filaments.
    Author: Ohtsuki I, Shiraishi F.
    Journal: J Biochem; 2002 May; 131(5):739-43. PubMed ID: 11983082.
    Abstract:
    We investigated the distribution of troponin C.I and troponin I along tropomyosin-actin filaments by immunoelectron microscopy and found that anti-troponin I antibody formed transverse striations at 38 nm intervals along the bundle of filaments of both troponin C.I-tropomyosin-actin and troponin I-tropomyosin-actin. Since the length of 38 nm corresponds to the repeating period of filamentous tropomyosin along actin double strands, the present study indicates that troponin I is located at a specific region of each tropomyosin, suggesting that a specific interaction between troponin I and tropomyosin is involved in determining the periodic distribution of troponin I along tropomyosin-actin filaments.
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