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  • Title: [Expression and clinical significance of MAGE-4 gene in human hepatocellular carcinoma].
    Author: Zhao H, Rui J, Cong X, Zhao Y, Wang S, Chen S, Wang Y, Wang Y, Leng X, Chen W.
    Journal: Zhonghua Gan Zang Bing Za Zhi; 2002 Apr; 10(2):100-2. PubMed ID: 11983123.
    Abstract:
    OBJECTIVE: To explore the possibility of MAGE-4 gene encoding protein used as a target for immunotherapy in HCC patients. METHODS: The expression of MAGE-4 gene in tumor tissues and tumor adjacent non-HCC liver tissues was examined by the RT-PCR method. The relationship between positive expression rate of MAGE-4 gene and other clinical and lab data including AFP, AFU, anti-HCV, HBsAg, AFP mRNA, and the diameter of the tumors in HCC patients was also determined. RESULTS: The positive expression rate of MAGE-4 gene was significantly higher in the tumor than in tumor surrounding tissues (38.7% vs 0%, P<0.01), while the positive expression rate of MAGE-4 gene had no relationship with the clinical and lab data (P>0.05). CONCLUSIONS: The high frequency of MAGE-4 gene expression in HCC suggests the possibility of MAGE-4 gene encoding protein as a target for immunotherapy in HCC patients, but the expression has no relationship with the tumor metastasis and the recurrence of HCC.
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