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  • Title: Orexin-1 receptor immunoreactivity in chemically identified target neurons in the rat hypothalamus.
    Author: Suzuki R, Shimojima H, Funahashi H, Nakajo S, Yamada S, Guan JL, Tsurugano S, Uehara K, Takeyama Y, Kikuyama S, Shioda S.
    Journal: Neurosci Lett; 2002 May 10; 324(1):5-8. PubMed ID: 11983281.
    Abstract:
    Immunohistochemistry and Western blotting were used to determine the distribution of orexin receptors in the rat brain. Strong orexin receptor 1 (OX1R) immunoreactivity was detected in the hypothalamus including the arcuate, ventromedial, and tuberomammillary nuclei that are involved in feeding regulation. The neuropeptide Y- and proopiomelanocortin-containing neurons of the arcuate nucleus, which act to stimulate or to inhibit feeding, respectively, displayed intense OX1R immunoreactivity by double immunostaining. Western blotting analysis yielded a 50-kDa major band of OX1R.
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