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  • Title: Hypothalamo-pituitary-adrenal function in intrinsic non-atopic asthma.
    Author: Collins JV, Bellamy D, Britton MG, Townsend J, Brown DJ.
    Journal: Thorax; 1975 Oct; 30(5):578-81. PubMed ID: 1198402.
    Abstract:
    Sixteen patients with intrinsic non-atopic asthma with persistent wheezing who had never been treated with corticosteroids showed normal adrenocortical responses to prolonged stimulation with Tetracosactin Depot. In a subgroup of six patients the hypothalamo-pituitary-adrenal (HPA) response to a standard insulin stress test was normal. It is concluded that impaired responsiveness of the HPA axis is unlikely to be a common factor in initiating or maintaining airways obstruction in patients with intrinsic asthma.
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