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  • Title: [Epstein-Barr virus infection in patients after bone marrow and heart transplantation].
    Author: Zawilińska B, Gruszka K, Piatkowska-Jakubas B, Garlicki M, Skotnicki A.
    Journal: Przegl Epidemiol; 2001; 55 Suppl 3():52-5. PubMed ID: 11984959.
    Abstract:
    UNLABELLED: Epstein-Barr virus (EBV) infections in immunosuppressed patients cause the severe clinical problems. Posttransplant lymphoproliferative disease (PTLD) might occur as a result of the latent EBV activation. OBJECTIVE: Occurrence of active EBV infection in heart and bone marrow transplant patients. METHODS: 68 serum samples obtained from 13 allogenic bone marrow and 20 heart transplant patients were tested by IF and ELISA methods. Antibodies against VCA, EA and EBNA antigens were measured. RESULTS: All patients showed the presence of anti-VCA IgG antibodies, thus all were seropositive. Three patients (9%) showed primary EBV infection while in 12 (36%) patients virus reactivation or reinfection was confirmed. CONCLUSIONS: 1. EBV infection in immunosuppressed patients is mainly caused by latent virus reactivation. 2. Type of EBV infection can be confirmed serologically only by the detection of specific anti-VCA, EA and EBNA antibodies. 3. The risk of PTLD in transplant patients creates the need for frequent monitoring.
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