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  • Title: [Effect of almitrine/raubasine on cerebral metabolism in the elderly].
    Author: Allain H, Bentué-Ferrer D.
    Journal: Presse Med; 2002 Mar 30; 31(12):562-4. PubMed ID: 11984975.
    Abstract:
    Recent neurobiological data has led to renewed interest in oxygen (O2). The discovery of neuroglobin, protein varyingly present in the brain, has been enhanced by the elucidation of the mechanisms through which oxygen intervenes in neuronal metabolism. Almitrine/raubasine activates the metabolism of hypoxic/ischemic neurones by increasing O2 bioavailability. This mechanism supports the effects on behaviour obtained in various animal models and the benefits observed during clinical trials in elderly patients presenting with cognitive defects.
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