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  • Title: Effect of repeated treatment with reboxetine on the central alpha1-adrenergic system.
    Author: Rogóz Z, Kolasiewicz W.
    Journal: Pol J Pharmacol; 2001; 53(6):663-7. PubMed ID: 11985343.
    Abstract:
    The obtained results indicate that repeated administration of reboxetine (selective noradrenaline reuptake inhibitor, without any affinity for neurotransmitter receptors) increased the responsiveness of alpha1-adrenergic system (potentiating the methoxamine-induced exploratory hyperactivity in rats and clonidine-induced aggressiveness in mice), as tricyclic antidepressants did. However, the question whether the increased functional responsiveness found in the present study is important for the clinical antidepressant efficacy, remains open.
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