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  • Title: Alu repeats and human genomic diversity.
    Author: Batzer MA, Deininger PL.
    Journal: Nat Rev Genet; 2002 May; 3(5):370-9. PubMed ID: 11988762.
    Abstract:
    During the past 65 million years, Alu elements have propagated to more than one million copies in primate genomes, which has resulted in the generation of a series of Alu subfamilies of different ages. Alu elements affect the genome in several ways, causing insertion mutations, recombination between elements, gene conversion and alterations in gene expression. Alu-insertion polymorphisms are a boon for the study of human population genetics and primate comparative genomics because they are neutral genetic markers of identical descent with known ancestral states.
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