These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The Mre11 complex: at the crossroads of dna repair and checkpoint signalling.
    Author: D'Amours D, Jackson SP.
    Journal: Nat Rev Mol Cell Biol; 2002 May; 3(5):317-27. PubMed ID: 11988766.
    Abstract:
    The Mre11 complex is a multisubunit nuclease that is composed of Mre11, Rad50 and Nbs1/Xrs2. Mutations in the genes that encode components of this complex result in DNA- damage sensitivity, genomic instability, telomere shortening and aberrant meiosis. The molecular defect that underlies these phenotypes has long been thought to be related to a DNA repair deficiency. However, recent studies have uncovered functions for the Mre11 complex in checkpoint signalling and DNA replication.
    [Abstract] [Full Text] [Related] [New Search]