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  • Title: Microbial transformation of danazol.
    Author: Choudhary MI, Azizuddin, Atta-ur-Rahman.
    Journal: Nat Prod Lett; 2002 Apr; 16(2):101-6. PubMed ID: 11990425.
    Abstract:
    Danazol (17beta-hydroxy-17alpha-pregna-2,4-dien-20-yno-[2,3-d] isoxazole) (1) on fermentation with Fusarium lini, Aspergillus niger, and Cephalosporium aphidicola yielded 17beta-hydroxy-2-(hydroxymethyl)-17-alpha-pregn-4-en-20-yn-3-one (2) and 17beta-hydroxy-2-(hydroxymethyl)-17 alpha-pregna-1,4-dien-20-yn-3-one (3), while the fermentation of 1 with Bacillus cerus yielded compound 2 only.
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