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  • Title: Bursa lymphocytes and IgM-containing cells in chicken embryos bursectomized at 52-64 hours of incubation.
    Author: Janković BD, Knezević Z, Isaković K, Mitrović K, Marković BM, Rajcević M.
    Journal: Eur J Immunol; 1975 Sep; 5(9):656-9. PubMed ID: 11993329.
    Abstract:
    A technique of surgical removal of the bursal primordium ("bursectomy") of chicken embryos at stage 17, approximately 52-64 hours and 29-32 somites, is described. The survival rate of bursectomized (Bx) embryos approached a level of 50% on the 21st day. About 20% of correctly Bx embryos exhibited malformations of the anal sphincter and the large intestine. Using a rabbit anti-bursacyte serum, which did not react with thymocytes, the specific bursa-derived cell (Bu) marker was detected on the surface of bursa, spleen, bone marrow and thymus lymphocytes. Early embryonic bursectomy caused a moderate depletion of Bu marker-bearing and IgM-containing cells. It has been postulated that embryonic Bu cells can be recruited from sites other than the bursa and in the absence of the bursa.
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