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  • Title: Protein phosphatase 2A methylation: a link between elevated plasma homocysteine and Alzheimer's Disease.
    Author: Vafai SB, Stock JB.
    Journal: FEBS Lett; 2002 May 08; 518(1-3):1-4. PubMed ID: 11997007.
    Abstract:
    Tau hyperphosphorylation is a central event in the development of Alzheimer's Disease (AD). Protein phosphatase 2A (PP2A) heterotrimer formation is necessary for efficient dephosphorylation of the tau protein. S-Adenosylmethionine-dependent carboxyl methylation is essential for the assembly of PP2A heterotrimers. Epidemiological evidence indicates that elevated plasma homocysteine is an independent risk factor for AD. Homocysteine is a key intermediate in the methyl cycle and elevated plasma homocysteine results in a global decrease in cellular methylation. We propose that the PP2A methylation system is the link relating elevated plasma homocysteine to AD.
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