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  • Title: Comparison of the effect of intrathecal endomorphin-1 and endomorphin-2 on spinal cord excitability in rats.
    Author: Grass S, Xu IS, Wiesenfeld-Hallin Z, Xu XJ.
    Journal: Neurosci Lett; 2002 May 24; 324(3):197-200. PubMed ID: 12009522.
    Abstract:
    We examined and compared the effects of intrathecal (i.t.) endomorphin-1 and endomorphin-2 on the nociceptive flexor reflex in decerebrate, spinalized, unanesthetized rats. I.t. endomorphin-1 and -2 induced a dose-dependent depression of the flexor reflex with an initial brief facilitatory effect. The magnitude of reflex facilitation and depression was similar between endomorphin-1 and -2, but the duration of depression was significantly longer for endomorphin-1 than endomorphin-2. The results suggested that the spinal antinociceptive effects of endomorphin-1 and -2 are similar, with endomorphin-1 being more resistant to enzymatic degradation.
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