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  • Title: Hemoglobin synthesis studies of a family with alpha-thalassemia trait and sickle cell trait.
    Author: Shaeffer JR, DeSimone J, Kleve LJ.
    Journal: Biochem Genet; 1975 Dec; 13(11-12):783-8. PubMed ID: 1200978.
    Abstract:
    The ratio of total globin alpha to beta chain synthesis was determined in reticulocytes isolated from the blood of the members of a black family, some of whom had sickle cell trait with low blood HbS concentrations (25-30%). The results support the hypothesis that sickle cell trait individuals with low HbS concentrations also carry a gene for alpha-thalassemia.
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