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  • Title: Comparison between saliva and serum lithium concentrations in patients treated with lithium carbonate.
    Author: Vlaar H, Bleeker JA, Schalken HF.
    Journal: Acta Psychiatr Scand; 1979 Nov; 60(5):423-6. PubMed ID: 120111.
    Abstract:
    The relation between serum and saliva lithium concentration was studied in patients treated with lithium carbonate. In 23 patients a highly variable saliva/serum ratio was found in simultaneous saliva and serum samples. In five patients studied during a period of 4-8 weeks three patients showed a high fluctuation in saliva/serum lithium ratio. In 20 patients saliva lithium concentrations varied unexpectedly in a second sample produced after 15 min. Although some authors report a high and stable relation between saliva and serum lithium concentration, we consider the saliva lithium level unreliable as a prediction of the serum lithium level in patients treated with lithium carbonate.
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