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  • Title: Effects of ADP and ATP on bovine fibrinogen- and ristocetin-induced platelet aggregation in Glanzmann's thrombasthenia.
    Author: Cohen I, Glaser T, Seligsohn U.
    Journal: Br J Haematol; 1975 Nov; 31(3):343-7. PubMed ID: 1201247.
    Abstract:
    With thrombasthenic platelets, aggregation induced by ristocetin (R) and bovine fibrinogen (BF) is reversible, provided ATP is not added to the system. ADP inhibits BF and R induced aggregation, and when added after the onset of aggregation causes rapid disaggregation. ATP prevents these inhibitory and disaggregation effects of ADP. A mechanism is suggested whereby co-operative effects occur between receptors in the membranes of thrombasthenic platelets.
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