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  • Title: Etomidate for procedural sedation in the emergency department.
    Author: Keim SM, Erstad BL, Sakles JC, Davis V.
    Journal: Pharmacotherapy; 2002 May; 22(5):586-92. PubMed ID: 12013357.
    Abstract:
    STUDY OBJECTIVE: To review our experience with etomidate in nonintubated patients in the emergency department. DESIGN: A 2-year retrospective chart review of consecutive patients receiving etomidate for sedation. SETTING: Emergency department of a university-based teaching hospital. PATIENTS: Forty-eight patients who underwent painful procedures in the emergency department. MEASUREMENTS AND MAIN RESULTS: Demographics, dosing information, recovery times, and adverse events were abstracted using a standardized data collection form. Forty-eight nonintubated patients were sedated with etomidate. Mean age was 34 years (range 6-80 yrs); 38 were men and 10 women; two were children. The mean initial dose of etomidate was 13 mg. Adverse events occurred in 11 (21%) patients. None sustained any substantial morbidity as indicated by need for intubation, prolonged emergency department stay, or hospital admission. CONCLUSION: Although controversial, etomidate holds promise as a potent sedative agent for patients undergoing painful procedures in the emergency department. A large prospective evaluation is needed to document the performance and complications of this agent.
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