These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effects of oestradiol and progesterone on the in vitro production of prostaglandin F2alpha by the guinea-pig uterus.
    Author: Naylor B, Poyser NL.
    Journal: Br J Pharmacol; 1975 Oct; 55(2):229-32. PubMed ID: 1201381.
    Abstract:
    1 The effects of oestradiol and progesterone on the production of F 2alpha by the guinea-pig uterus in vitro have been studied. 2 Ovariectomized guinea-pigs were treated with oestradiol benzoate, progesterone, or a combination of these hormones. The uteri were homogenized and incubated and the prostaglandin F2alpha produced was measured by radiommunoassay or combined gas chromatography-mass spectrometry (g.c.-m.s.). Oestradiol treatment or progesterone followed by oestradiol caused a significant increase in prostaglandin F2alpha synthesis compared with control values, whereas progesterone treatment caused no significant increase. 3 The uteri from guinea-pigs on day 7 of the oestrous cycle were split into four parts, and each part homogenized and incubated either alone or in the presence of oestradiol-17beta, progesterone, or a combination of these hormones. Prostaglandin F2alpha was measured by g.c.-m.s. Oestradiol was found to increase prostaglandin F2alpha synthesis by the uterus whereas progesterone had no effect. However, progesterone did inhibit the response to oestradiol. 4 Oestradiol treatment of the guinea-pig uterus causes an increase in capacity to produce prostaglandin F2alpha in vitro. The role of progesterone is difficult to interpret.
    [Abstract] [Full Text] [Related] [New Search]