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  • Title: [Plerosis of cDNA array of normal human nasopharyngeal tissue and nasopharyngeal carcinoma].
    Author: Han W, Li H, Xie L, Xu L, Zhang L, Yao K.
    Journal: Zhonghua Zhong Liu Za Zhi; 2002 Mar; 24(2):114-7. PubMed ID: 12015028.
    Abstract:
    OBJECTIVE: To compare gene expression gene profile of nasopharyngeal carcinoma (NPC) tissue with that of normal nasopharyngeal tissues by cDNA array and to discuss possible functions of DNA repair-related genes in NPC tissue. METHODS: After hybridization of atlas human cancer cDNA expression array 7742 - 1, atlas hybridization results were analyzed by Atlas Image 1.01 a software package. Using RT-PCR was used to confirm the results. RESULTS: Of 63 differentially expressed genes in quadrangle C including DNA damage response, repair & recombination-related genes, 6 DNA repair-related genes were up-regulated, 12 were down-regulated. CONCLUSION: DNA repair-related genes may be involved in patho-physiological process of nasopharyngeal carcinoma.
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