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  • Title: Heterogeneous distribution of DNA alkylation products in rat liver chromatin after in vivo administration of N,N-di[14C]methylnitrosamine.
    Author: Cooper HK, Margison GP, O'Connor PJ, Itzhaki RF.
    Journal: Chem Biol Interact; 1975 Dec; 11(6):483-92. PubMed ID: 1201613.
    Abstract:
    Poly-l-lysine (PL) binds to about 50% of chromatin DNA, rendering it resistant to degradation by DNAase I. Separation of the unbound DNA as acid-soluble nucleotides allows the fractionation of chromatin DNA into two zones. After in vivo administration of N,N-di[14C]methylnitrosamine, the amount of alkylation in DNA was found to be lower in the polylysine-binding regions. Some possible reasons for this heterogeneous distribution are discussed.
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