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  • Title: Suppressive effect of cyproheptadine on L-DOPA-induced growth hormone release in man.
    Author: Nakai Y, Imura H.
    Journal: Endocrinol Jpn; 1975 Aug; 22(4):357-60. PubMed ID: 1201741.
    Abstract:
    In order to elucidate the relationship between dopaminergic and serotoninergic mechanisms in regulating secretion of human growth hormone (hGH), the effect of cyproheptadine, an antiserotoninergic agent, on l-DOPA-induced hGH secretion was studied in normal subjects. Oral administration of 500 mg of l-DOPA caused a rise in plasma hGH in 6 of 7 subjects studied. This rise in plasma hGH was significantly blunted by the intravenous infusion of 5 mg of cyproheptadine. These results suggest the close relationship between dopamine and serotonin in the control of hGH secretion.
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