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Title: Serotonin and benzylamine oxidation by type A and type B MAO of rat brain in presence of organophosphate pesticides. Author: Nag M, Nandy N. Journal: Indian J Exp Biol; 2001 Aug; 39(8):802-6. PubMed ID: 12018584. Abstract: Organophosphate (OP) pesticides, monocrotophos (MCP), dichlorvos (DDVP) and phosphamidon significantly inhibit both MAO-A and MAO-B activities in rat brain mitochondria. The inhibition of MAO-A by MCP is reversible whereas the inhibition by DDVP and phosphamidon is irreversible. MAO-B is inhibited irreversibly by all these organophosphates suggesting that the mechanism of action of OP pesticides is through phosphorylation of serine residue present in active centre of MAO.[Abstract] [Full Text] [Related] [New Search]