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  • Title: Group III mGluR-mediated depression of sensory synaptic transmission.
    Author: Krieger P, El Manira A.
    Journal: Brain Res; 2002 May 24; 937(1-2):41-4. PubMed ID: 12020860.
    Abstract:
    The effect of L-AP4, a group III mGluR agonist, on sensory synaptic transmission in the lamprey spinal cord has been analyzed. Paired recordings were made between cutaneous mechanosensory neurons (dorsal cells) and postsynaptic spinobulbar giant interneurons. L-AP4 reduced the monosynaptic dorsal cell-evoked EPSP, but at concentrations higher (200-500 microM) than those necessary to depress reticulospinal axon-evoked EPSPs. Stimulation of the dorsal column, which contains dorsal cell axons and the axons of putative nociceptive and theromosensory axons, elicited compound EPSPs that were consistently depressed by L-AP4. Sensory inputs in the lamprey are thus inhibited by group III mGluRs.
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