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  • Title: Relaxant effects of the essential oil of Ocimum gratissimum on isolated ileum of the guinea pig.
    Author: Madeira SV, Matos FJ, Leal-Cardoso JH, Criddle DN.
    Journal: J Ethnopharmacol; 2002 Jun; 81(1):1-4. PubMed ID: 12020920.
    Abstract:
    The effects of the essential oil of Ocimum gratissimum L. (Labiatae) (EOOG) on guinea pig ileum were studied. EOOG (0.1-1000 microg/ml) reversibly and concentration-dependently relaxed the basal tone of the ileum and reversed the tonic contractions induced by 60 mM KCl and 10 microM acetylcholine, with IC(50) values of 23.8+/-5.2, 18.6+/-4.0 and 70.0+/-4.6 microg/ml, respectively. Our results show that EOOG exerts relaxant effects on intestinal smooth muscle, consistent with the popular use of the plant to treat gastrointestinal disorders.
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