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  • Title: Protective molecular mimicry in experimental myasthenia gravis.
    Author: Im SH, Barchan D, Feferman T, Raveh L, Souroujon MC, Fuchs S.
    Journal: J Neuroimmunol; 2002 May; 126(1-2):99-106. PubMed ID: 12020961.
    Abstract:
    Protein databases were searched for microbial sequences that bear amino acid similarities with identified T- or B-cell epitopes within the human alpha-subunit of acetylcholine receptor (AChR). One peptide, derived from Haemophilus influenzae, exhibits 50% homology to an identified T-cell epitope of AChR alpha-subunit. This peptide was shown to have a protective effect in experimental autoimmune myasthenia gravis (EAMG). Pretreatment of rats with the mimicry peptide attenuated the induction and progression of EAMG. These effects were accompanied by a reduced T-cell response to AChR, diminished IL-2, IL-12, IFN-gamma and IL-4 levels, as well as decreased humoral response to self-AChR.
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