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  • Title: Corticosteroid-responsive diabetes mellitus associated with autoimmune pancreatitis: pathological examinations of the endocrine and exocrine pancreas.
    Author: Tanaka S, Kobayashi T, Nakanishi K, Okubo M, Odawara M, Murase T, Hashimoto M, Watanabe G, Matsushita H, Inoko H, Takeuchi K.
    Journal: Ann N Y Acad Sci; 2002 Apr; 958():152-9. PubMed ID: 12021096.
    Abstract:
    Histopathological changes of biopsied pancreata were examined in three diabetic patients with autoimmune chronic pancreatitis (ACP). We found intra- and periinsular mononuclear cell (MNC)-mainly CD8+ T cell-infiltration as well as MNC infiltration around the ductal cells. Islet beta cell volume decreased significantly. Some ductal cells expressed insulin and insulin promoter factor-1 concomitantly in the affected pancreas. These findings provide new insight toward understanding the pathological mechanisms of corticosteroid treatment-responsive diabetes associated with ACP.
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