These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Gabapentin in children and adolescents with epilepsy].
    Author: Herranz JL.
    Journal: Rev Neurol; ; 34(4):384-7. PubMed ID: 12022057.
    Abstract:
    OBJECTIVE: We analyze the studies published on gabapentin (GBP) in children and adolescents with epilepsy, both clinical studies, in which it is used to treat patients with partial seizures refractory to treatment with other drugs, and in other studies of its use as monotherapy. PATIENTS AND METHODS: We report the results of a multicentric observational study carried out in Spain using GBP as monotherapy for 52 adolescents with partial seizures with no previous treatment (32) or as a second alternative treatment (20). RESULTS: We showed evident clinical efficacy, with a reduction of >50% in the frequency of seizures in 79% of the cases and abolition of seizures in 60%, after six months of treatment with GBP. At the same time the drug is very well tolerated, with adverse effects in 7.7% of cases. The drug was only suspended on account of adverse effects in one patient (1.9%). Simultaneously all the basic items of the QOLIE 10 questionnaire were improved after six months of treatment. CONCLUSION: GBP is an effective drug which is well tolerated by children and adolescents with partial crises, when used in polytherapy or as monotherapy.
    [Abstract] [Full Text] [Related] [New Search]