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  • Title: Effect of IL-18 on IL-1beta and sIL-1RII production by human neutrophils.
    Author: Jabłońska E, Izycka A, Wawrusiewicz N.
    Journal: Arch Immunol Ther Exp (Warsz); 2002; 50(2):139-41. PubMed ID: 12022703.
    Abstract:
    In the present study we investigated the effect of interleukin 18 (IL-18) on the production of IL-1beta and soluble IL-1 receptor II (sIL-1RII) by human neutrophils. The results obtained indicate that recombinant human IL-18 (rhIL-18) induces IL-1beta and, to a lesser extent, sIL-1RII production by human neutrophil isolated from peripheral blood. However, this effect was less important than lipopolysaccharide (LPS) stimulation. Additionally, our observations suggest that IL-18 can induce priming of neutrophils for IL-1beta and, to a lesser extent, sIL-IRII production by LPS-stimulated cells. The ability of IL-18 to serve as an effective modulator for IL-1beta and its regulatory protein may have significance in the inflammatory and immune reactions mediated by IL-1beta.
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