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  • Title: Respiratory oscillations in yeast: clock-driven mitochondrial cycles of energization.
    Author: Lloyd D, Eshantha L, Salgado J, Turner MP, Murray DB.
    Journal: FEBS Lett; 2002 May 22; 519(1-3):41-4. PubMed ID: 12023015.
    Abstract:
    Respiratory oscillations in continuous yeast cultures can be accounted for by cyclic energization of mitochondria, dictated by the demands of a temperature-compensated ultradian clock with a period of 50 min. Inner mitochondrial membranes show both ultrastructural modifications and electrochemical potential changes. Electron transport components (NADH and cytochromes c and c oxidase) show redox state changes as the organisms cycle between their energized and de-energized phases. These regular cycles are transiently perturbed by uncouplers of energy conservation, with amplitudes more affected than period; that the characteristic period is restored after only one prolonged cycle, indicates that mitochondrial energy generation is not part of the clock mechanism itself, but is responding to energetic requirement.
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