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  • Title: Activated reptilase clot retraction of dog platelet-rich plasma: differences with human platelet-rich plasma.
    Author: De Clerck F, Verheyen A, Vermylen J, Reneman R.
    Journal: Scand J Haematol; 1975 Dec; 15(5):347-58. PubMed ID: 1202624.
    Abstract:
    The retraction of dog platelet-rich plasma (PRP) clotted with Reptilase in the presence of inducers and inhibitors of the platelet adhesion-aggregation reaction was studied. In contrast to human cells, dog platelets fail to support retraction in an ADP-Reptilase system. With Thrombofax as aggregation inducer, slight (without additional CaCl2-MgCl2) to moderate (with additional CaCl2-MgCl2) retraction occurs. In contrast to human samples, such retraction is inhibited by platelet release inhibitors. Electron-microscopic examinations show that Thrombofax, but not ADP, induces the formation of large cytoplasmic protrusions from dog platelets. Such formation is inhibited by release-inhibitors. The results of the study support the concept that platelet pseudopod formation, rather than the release reaction, is a prerequisite for clot retraction.
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