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  • Title: A stereoselective synthesis of BMS-262084, an azetidinone-based tryptase inhibitor.
    Author: Qian X, Zheng B, Burke B, Saindane MT, Kronenthal DR.
    Journal: J Org Chem; 2002 May 31; 67(11):3595-600. PubMed ID: 12027669.
    Abstract:
    A highly stereoselective synthesis of the novel tryptase inhibitor BMS-262084 was developed. Key to this synthesis was the discovery and development of a highly diastereoselective demethoxycarbonylation of diester 12 to form the trans-azetidinone 13. BMS-262084 was prepared in 10 steps from D-ornithine in 30% overall yield.
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