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  • Title: Antiangiogenic activity of synthetic dihydrobenzofuran lignans.
    Author: Apers S, Paper D, Bürgermeister J, Baronikova S, Van Dyck S, Lemière G, Vlietinck A, Pieters L.
    Journal: J Nat Prod; 2002 May; 65(5):718-20. PubMed ID: 12027748.
    Abstract:
    A series of synthetic dihydrobenzofuran lignans, obtained by biomimetic oxidative dimerization of caffeic or ferulic acid methyl ester followed by derivatization reactions, was tested for its antiangiogenic activity in the CAM (chorioallantoic membrane) assay. The dimerization product of caffeic acid methyl ester (2a) (methyl (E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-3-methoxycarbonyl-2,3-dihydro-1-benzofuran-5-yl]prop-2-enoate) showed a pronounced antiangiogenic activity, especially the 2R,3R-enantiomer.
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